Medication Misuse and Dependence Among Elderly

Summary

The project focuses on investigating problematic medication use, especially overuse of potentially addictive drugs among the elderly.

The investigators aim firstly to develop and validate instruments for detecting and describing behavioral aspects and consequences of dependence on, and misuse of, prescription medication among elderly.

In addition to evaluating diagnostic utility of screening instruments, the investigators aim to identify and report characteristics, risk factors and consequences of medication misuse and dependence among the elderly.

Conditions

• Mild Cognitive Impairment
• Elderly
• Substance-Related Disorders

Interventions

DIAGNOSTIC_TEST

Substance misuse screening

Diagnostic and Statistical manual of mental disorders, version 4 (DSM-IV)/MINI-international Neuropsychiatric interview (MINI interview) for Diagnostics of dependence, additional questions for DSM-V classification, severity of dependence scale (SDS)

DIAGNOSTIC_TEST

EQ-5D

Health related Quality of life

DIAGNOSTIC_TEST

Impulsivity screening

Barratts impulsivity test v. 11, Behavioural inhibition/behavioural activation test

DIAGNOSTIC_TEST

Cognitive screening

Minimental state examination (MMSE), Hospital anxiety and depression scale (HADS), Trail-making test, clock drawing test

DIAGNOSTIC_TEST

Functional tests

Timed up and go (TUG), Single leg balancing test (SLB)

DIAGNOSTIC_TEST

Cognistat

Assessment of cognitive domains

DIAGNOSTIC_TEST

Neuropsychological profiling

Controlled Oral Word Association Test, Categorical fluency tests, Wechsler Adult Intelligence Scale, Color-Word Interference Test (CWIT) from the Delis-Kaplan Executive Function test

OTHER

Clinical interview

Interview for sociodemographics, utilisation of health care, economic varables, The De Jong Gierveld Loneliness Scale

OTHER

Medication use

Detailed screen of used medications, interactions, side effects in electronic patient registry

OTHER

Comorbidity

Charlson comorbidity index and Cumulated illness rating scale (CIRS) based on electronic patient registry

Sponsors & Collaborators

• King's College London

  collaborator OTHER

• University of Oslo

  collaborator OTHER

• University Hospital, Akershus

  lead OTHER

Principal Investigators

• Jorunn Rugkåsa, PhD · Coordinator of overall research program

Eligibility

Min Age

65 Years

Max Age

90 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-05-03

Primary Completion

2021-02-01

Completion

2024-12-31

Countries

• Norway