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Prevention of Radial Artery Occlusion After Transradial Access Using Nitroglycerin

NCT03158532 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 2040

Last updated 2024-12-09

Study results available
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Summary

The radial approach for a coronary angiography has became popular in several centers because of its simplicity and fewer complications. The radial artery occlusion (RAO) is the main inconvenient and impose a limitation of future use of the radial artery as an access site for catheterization in the future. Several strategies have been used to decrease the incidence of RAO (heparin, patent hemostasis, etc). Nitrates in intra-arterial have been widely studied in prevention of this spasm. Current data show that nitroglycerin intra-arterial at the end of the procedure reduce the incidence of RAO. The hypothesis that use of nitroglycerin at the start of catheterization would have the same effect was not tested.

Conditions

  • Injury of Radial Artery

Interventions

DRUG

Nitroglycerin I

500 microgram of Nitroglycerin intra-arterially administered through the radial sheath, right after sheath placement and before catheterization.

DRUG

Placebo I

Saline 0,9% intra-arterially administered through the radial sheath, right after sheath placement and before catheterization.

DRUG

Nitroglycerin II

500 microgram of Nitroglycerin intra-arterially administered through the radial sheath, just before sheath removal and before hemostasis.

DRUG

Placebo II

Saline 0,9% intra-arterially administered through the radial sheath, just before sheath removal and before hemostasis.

Sponsors & Collaborators

  • Instituto de Cardiologia de Santa Catarina

    lead OTHER

Principal Investigators

  • Roberto L da Silva, MD · Instituto de Cardiologia de Santa Catarina

  • José R Costa Júnior, PhD · Instituto Dante Pazzanese de Cardiologia

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
FACTORIAL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-07-06
Primary Completion
2021-10-01
Completion
2021-11-01

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03158532 on ClinicalTrials.gov