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Evaluation of the Impact of Reduced Oxygen Concentration on Live Birth Rate

NCT03147872 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 280

Last updated 2021-05-19

No results posted yet for this study

Summary

Clinical in vitro fertilization relies on successful embryo culture. The primary goal of embryo culture is to attempt to recapitulate the in vivo conditions as much as possible. In the past decade, the majority embryo culture has been performed at 5% oxygen due to the discovery that the oxygen tension in the fallopian tube (where the embryo is located for the first 3 days after fertilization) is 5%. However, relatively recent studies have demonstrated that the oxygen tension in the uterus (where the embryo is located after day 3) is closer to 2%. This study is a randomized controlled trial that will compare pregnancy rates between embryos cultured in 2% versus 5% after day 3 of development.

Conditions

Interventions

OTHER

2% Oxygen

2% oxygen concentration in the incubator in which embryos are being cultured after day 3 of development

Sponsors & Collaborators

  • Instituto Universitario IVI

    collaborator OTHER

  • Reproductive Medicine Associates of New Jersey

    lead OTHER

Principal Investigators

  • Scott Morin, MD · Reproductive Medicine Associates of New Jersey

  • Daniel J Kaser, MD · Reproductive Medicine Associates of New Jersey

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-05-15
Primary Completion
2020-12-31
Completion
2021-01-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03147872 on ClinicalTrials.gov