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Ibuprofen Gel or Capsaicin Cream for my Painful Knee Osteoarthritis?

NCT03146689 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 22

Last updated 2019-04-18

No results posted yet for this study

Summary

Despite evidence that topical non-steroidal anti-inflammatory drugs (NSAIDs) and capsaicin are effective in osteoarthritis (OA), it is still unclear why they work for some people but not others. The investigators are undertaking an individual patient data (IPD) meta-analysis to identify responders according to patient characteristics, however, no studies report the presence of synovial hypertrophy or neuropathic-like pain. These two traits are of interest as they may be used to optimise the treatment effects of the two drugs which work via different mechanisms to reduce pain in OA. The investigators are therefore conducting this pilot n-of-1 trial series.

This pilot n-of-1 trial series will investigate whether a person with OA, who has a different balance between inflammatory and neuropathic pain, shows a preference between these mechanistically different treatments. The trial will also be used to offer recommendations on the use of n-of-1 trial series for individualised (precision) medicine in OA.

Conditions

  • Osteoarthritis, Knee

Interventions

DRUG

Topical NSAID

Applied four times daily

DRUG

Topical Capsaicin

Applied four times daily

Sponsors & Collaborators

  • Arthritis Research UK Pain Centre

    collaborator UNKNOWN

  • Nottingham University Hospitals Charity

    collaborator UNKNOWN

  • University of Nottingham

    lead OTHER

Principal Investigators

  • Weiya Zhang, PhD · University of Nottingham

Study Design

Allocation
NA
Purpose
OTHER
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
40 Years
Max Age
95 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-08-04
Primary Completion
2018-10-16
Completion
2018-10-16

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03146689 on ClinicalTrials.gov