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Prevalence of Hypotension Associated With Preload Dependence During Continuous Renal Replacement Therapy

NCT03139123 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 42

Last updated 2021-01-25

No results posted yet for this study

Summary

Per-dialytic hypotension is common in Intensive Care Unit patients under continuous renal replacement therapy, and occurs in nearly 50% of the patients. To date, there is a lack of study having characterized the underlying mechanism of hypotension in this setting. New diagnostic methods are now available with high reliability to identify hypovolemia as the underlying cause of hypotension, among which change in cardiac index during passive leg raising may be the less affected by restrictive validity criteria. A change in cardiac index greater than 10% during this test is highly predictive of preload dependence, i.e the probability than cardiac index will increase if cardiac preload increases.

The aim of this study is then to identify, among hypotensive episodes occurring during renal replacement therapy in Intensive Care Unit patients, the percentage of episodes related to preload dependence as identified by passive leg raising.

Conditions

  • Kidney Injury
  • Renal Failure, Acute

Interventions

OTHER

Hemodynamic monitoring during passive leg raising

Measurement of hypotensive episodes related to preload dependance.

Sponsors & Collaborators

  • Hospices Civils de Lyon

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-05-18
Primary Completion
2020-08-29
Completion
2020-11-21

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03139123 on ClinicalTrials.gov