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Impact of Residual Syntax Score and Syntax Revascularization Index on Outcomes of ACS Patients With Multi-Vessel Disease

NCT03138473 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 149

Last updated 2022-02-22

No results posted yet for this study

Summary

The investigators want to assess the use of the residual SYNTAX score and the SYNTAX Revascularization Index as predictors for in-hospital outcomes and mid-term (6 months to 1 year) outcomes in patients with multi-vessel disease (MVD) who undergo PCI in the setting of STEMI or NSTEACS. Both values will be calculated in a number of patients over one year, and the relationship between both values and patient outcomes will be evaluated.

Conditions

  • STEMI - ST Elevation Myocardial Infarction
  • Multi Vessel Coronary Artery Disease
  • NSTEMI - Non-ST Segment Elevation MI
  • ACS - Acute Coronary Syndrome

Interventions

DIAGNOSTIC_TEST

Residual SYNTAX Score

The baseline SYNTAX score and the residual SYNTAX score (rSS) are calculated by summing up the individual scores for each lesion with a diameter stenosis ≥50% in vessels with a diameter ≥ 1.5 mm in the angiography obtained before and after the procedure. The SYNTAX algorithm of scoring is fully described elsewhere. The modified Age, Creatinine, and Ejection Fraction (ACEF) score is calculated based on the age, creatinine clearance (CrCl) and left ventricular ejection fraction (LVEF), using the formula age/LVEF +1 point for every 10 ml/min/1.73 m2 reduction of CrCl below 60 ml/min/1.73 m2 (1 point for CrCl between 59 and 50, 2 points for CrCl between 49 and 40 and 3 points for CrCl between 39 and 30 ml/min/1.73 m2). The CrCl is calculated via the Cockroft-Gault equation using age, gender weight and serum creatinine before PCI. The baseline SYNTAX score was then multiplied by the modified ACEF score to obtain the baseline clinical SYNTAX score.

DIAGNOSTIC_TEST

SYNTAX Revascularization Index

The SYNTAX Revascularization Index (SRI), representing the proportion of CAD burden treated by PCI, was calculated using the following formula: SRI= (1-\[rSS/bSS\]) ×100.

Sponsors & Collaborators

  • Assiut University

    lead OTHER

Principal Investigators

  • Salwa R. Dimitry, MD · Department of Cardiology, Assiut University Faculty of Medicine

  • Tarek A. Nagib, MD · Department of Cardiology, Assiut University Faculty of Medicine

  • Khaled M. Elmaghraby, MD · Department of Cardiology, Assiut University Faculty of Medicine

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-07-01
Primary Completion
2021-06-30
Completion
2021-06-30

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03138473 on ClinicalTrials.gov