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Stress and Treatment Response in Puerto Rican Children With Asthma

NCT03134755 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 249

Last updated 2025-02-11

No results posted yet for this study

Summary

This study aims to first determine whether high child stress leads to reduced response to common treatmenIs for asthma (inhaled corticosteroids and short-acting bronchodilators), and then to identify DNA methylation differences leading to stress-induced treatment resistance among children with asthma.

Conditions

  • Asthma in Children

Interventions

DRUG

Inhaled corticosteroid (mometasone)

The investigators are not measuring the effect of the intervention (ICS), but rather the effect of stress (which is not being intervened on), and this is thus an observational study. The ICS is given to children with asthma in whom an ICS is clinically indicated

Sponsors & Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • University of Pittsburgh

    lead OTHER

Principal Investigators

  • Juan C Celedon, MD, DrPH · University of Pittsburgh

Eligibility

Min Age
8 Years
Max Age
20 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-05-15
Primary Completion
2022-05-18
Completion
2022-05-18

Countries

  • United States
  • Puerto Rico

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03134755 on ClinicalTrials.gov