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Effect of Genetic Polymorphism on the Clinical Outcome of Patients With Heart Failure

NCT03122834 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 246

Last updated 2025-02-20

No results posted yet for this study

Summary

Heart failure (HF) is one the most common cause of hospitalization and represents the end stage of a variety of heart conditions; it is associated with significant morbidity and mortality.The pathophysiology of HF is centered on increased activity in the adrenergic and renin-angiotensin-aldosterone systems (RAAS), which leads to vasoconstriction and fluid restriction with further deleterious effect on cardiac function. Β-blockers, angiotensin converting enzyme inhibitors (ACEIs)/angiotensin II receptor blockers (ARBs) and aldosterone antagonists reduce activity in these pathways and have shown prognostic benefit, thus are the foundation of HF therapy.There is a growing body of evidence that variation in proteins within the sympathetic axis and RAAS influence drug response thus increasingly pharmacogenetics of HF research is being sought as a way to optimize HF treatment and advance new drug development in this area.

Conditions

Sponsors & Collaborators

  • Misr International University

    collaborator OTHER

  • National Heart Institute

    collaborator UNKNOWN

  • Ain Shams University

    lead OTHER

Principal Investigators

  • Neven M. Sarhan, PhD · Misr International University

  • Mona F. Schaalan, PhD · Misr International University

  • Bassem Zarif, MD · National Heart Institute

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-04-15
Primary Completion
2024-04-10
Completion
2024-06-14

Countries

  • Egypt

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03122834 on ClinicalTrials.gov