MedTrace Logo

Estimation of Paracetamol in Urine to Assess the Diurnal Variation

NCT03122561 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 46

Last updated 2018-07-13

No results posted yet for this study

Summary

Paracetamol is an antipyretic drug that is taken orally at different times of the day in same dose. It is excreted mainly through renal route which may show diurnal variation. In this study, urinary excretion of paracetamol of 41 healthy men of same age group will be measured by HPLC after oral administration of 500 mg paracetamol tablet at morning, midday and night. The measured values will be compared in order to adjust doses of oral paracetamol at different times of the day.

Conditions

  • Diurnal Variation of Paracetamol Excretion

Interventions

DRUG

Paracetamol 500 mg tablet at morning

Single dose oral paracetamol will be administered at 8.00 am

DRUG

Paracetamol 500 mg tablet at midday

Single dose oral paracetamol will be administered at 2.00 pm

DRUG

Paracetamol 500 mg tablet at night

Single dose oral paracetamol will be administered at 8.00 pm

Sponsors & Collaborators

  • Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

    lead OTHER

Principal Investigators

  • Mir Misbahuddin, PhD · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
19 Years
Max Age
23 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-11-03
Primary Completion
2018-01-30
Completion
2018-01-30

Countries

  • Bangladesh

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03122561 on ClinicalTrials.gov