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The Markers and Paracetamol Poisoning Study 2

NCT03497104 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 464

Last updated 2023-11-15

No results posted yet for this study

Summary

Paracetamol overdose is one of the most common medical emergencies. Annually in the UK, 100,000 people seek medical attention and 50,000 need hospital admission. Treatment is with the antidote acetylcysteine (NAC), which is effective but takes 21 hours to administer intravenously and frequently produces adverse reactions.

Current tools that are used to decide who needs treatment are inadequate. this trial team have identified and validated new blood tests that accurately identify those patients at risk of liver injury by quantifying the fundamental in vivo toxicity mechanisms.

This study aim to gain further samples in order to develop a new point-of-care test specifically for the detection of liver damage.

Conditions

  • Paracetamol Overdose

Interventions

OTHER

Surplus blood tests

Surplus blood donation

Sponsors & Collaborators

  • NHS Lothian

    lead OTHER_GOV

Principal Investigators

  • James Dear · University of Edinburgh

Eligibility

Min Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-07-01
Primary Completion
2023-05-31
Completion
2023-05-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03497104 on ClinicalTrials.gov