MedTrace Logo

Cerebral Blood Supply During Cardiopulmonary Bypass

NCT03117712 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2019-03-06

No results posted yet for this study

Summary

Postoperative delirium is an acute and fluctuating state of confusion and disorientation with an incidence of 25-70% after cardiac surgery. Possible reasons for this multifactorial complication are hypoperfusion, cerebral microembolization and inflammatory response, which eventually lead to regional or global imbalance between cerebral oxygen demand and supply. Adequate cerebral blood supply depends sufficient blood supply via the vertebral arteries and the internal carotid arteries. The aim of this preliminary study is to investigate if patients who develop delirium after open-heart surgery show differences in their cerebral blood flow during cardiopulmonary bypass (CPB) in extracerebral arterial vessels compared to those patients without delirium.

Conditions

  • Postoperative Delirium

Interventions

DIAGNOSTIC_TEST

Delirium Scores

* Confusion Assessment method for the ICU (CAM-ICU) and * The Intensive Care Delirium Screening Checklist (ICDSC) Delirium Scores will be measured at the following timepoints: 1. Postoperative day (POD) 1 2. POD 2 3. POD 5

DIAGNOSTIC_TEST

Carotis duplex sonography

Carotis duplex sonography for perfusion flow will be evaluated at the following timepoints: 1. Before induction of anaesthesia 2. Before going on cardiopulmonary bypass (CBP) 3. During CPB, 5 min after aortic cross clamping 4. After CPB 5. 24 hours after CPB

DIAGNOSTIC_TEST

TCD for detection of HITS

Transcranial Doppler ultrasound (TCD) for detection and differentiation of high-intensity transient signals (HITS) in both middle cerebral arteries (MCAs) into artefacts, solid, and gaseous cerebral microemboli (CME) will be performed at the following timepoints: 1. During cannulation of the ascending aorta 2. After aortic cross-clamp 3. After opening of the aortic cross-clamp 4. During decannulation

Sponsors & Collaborators

  • Medical University of Vienna

    lead OTHER

Principal Investigators

  • Ulrike Weber, M.D. · Medical University of Vienna

Eligibility

Min Age
18 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-05-01
Primary Completion
2018-06-30
Completion
2018-12-31

Countries

  • Austria

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03117712 on ClinicalTrials.gov