Structural and Functional Connectivity of Brainstem Monoamine Pathways in Treatment Resistant Depression
NCT03109717 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 11
Last updated 2021-06-18
Summary
Study TRD subjects' resistance to at least 2 different antidepressants, we hypothesize that because of their significant depression and treatment resistant status they are most likely to exhibit BSMN pathway abnormalities.
Conditions
Interventions
- DRUG
-
Monoamine Oxidase Inhibitor (MAOI)
Monoamine Oxidase Inhibitor
Sponsors & Collaborators
-
Kathryn O'Connor
lead OTHER
Principal Investigators
-
Amit Anand, MD · The Cleveland Clinic
Eligibility
- Min Age
- 18 Years
- Max Age
- 65 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2016-07-31
- Primary Completion
- 2020-11-30
- Completion
- 2021-05-31
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Clinical Trial of the Use of Ketamine in Treatment Resistant Depression
NCT02610712 ·Status: UNKNOWN ·Phase: PHASE4
-
Brain Energy Metabolism in Individuals With Major Depressive Disorder Receiving Escitalopram
NCT00183677 ·Status: COMPLETED ·Phase: PHASE4
-
A Study of Ketamine in Patients With Treatment-resistant Depression
NCT01627782 ·Status: COMPLETED ·Phase: PHASE2
-
Intramuscular Ketamine Versus Aripiprazole and Escitalopram in the Treatment of Resistant Depression
NCT04234776 ·Status: UNKNOWN ·Phase: PHASE4
-
Ketamine in the Treatment of Depression
NCT01558063 ·Status: COMPLETED ·Phase: PHASE2
-
A New Treatment Approach for Major Depressive Disorder Based Upon Targeting Monoamine Oxidase A (MAO-A)
NCT02269540 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Positron Emission Tomography Assessment of Ketamine Binding of the Serotonin Transporter
NCT02717052 ·Status: UNKNOWN ·Phase: PHASE2
-
Functional Neuroimaging in Depression
NCT00343070 ·Status: COMPLETED ·Phase: PHASE2
-
Ketamine for Depression: An MRI Study
NCT02544607 ·Status: COMPLETED ·Phase: PHASE4
-
Study of Brain Response to Emotional Pictures Using a Magnetic Resonance Imaging (fMRI) While on Escitalopram
NCT00707863 ·Status: COMPLETED ·Phase: PHASE4
-
Repeated Neurocognitive Measurements in Depressed Patients
NCT04916548 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Neural Circuit Effects of Ketamine in Depression
NCT06213324 ·Status: RECRUITING ·Phase: PHASE4
-
Mechanisms of Antidepressant Non-Response in Late-Life Depression
NCT01931202 ·Status: COMPLETED ·Phase: NA
-
Neural, Genetic, and Peripheral Correlates of SSRI Pharmaco-Response
NCT01251471 ·Status: COMPLETED ·Phase: PHASE4
-
Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression
NCT03973268 ·Status: RECRUITING ·Phase: PHASE1
-
Study Where Pharmaco Magnetic Resonance Imaging (MRI) Effects of AZD6765 Will be Compared to Placebo in Depressive Male and Female Subjects
NCT01046630 ·Status: COMPLETED ·Phase: PHASE1
-
Neuroimaging Study of Bupropion Treatment in Patients With Major Depressive Disorder
NCT01541475 ·Status: COMPLETED ·Phase: PHASE4
-
NMDA Modulation in Antidepressant Nonresponders With Major Depressive Disorder
NCT05136755 ·Status: RECRUITING ·Phase: PHASE2
-
A Naturalistic Study of Ketamine for Treatment Resistant Mood Disorders
NCT04226963 ·Status: COMPLETED
-
Ketamine in Adolescents With Treatment-Resistant Depression
NCT02078817 ·Status: COMPLETED ·Phase: PHASE2
-
Behavioral and Electrophysiological Effects of Ketamine in Treatment-Resistant Depression
NCT04239963 ·Status: COMPLETED
-
Ketamine Infusion for Treatment-resistant Major Depressive Disorder
NCT01582945 ·Status: COMPLETED ·Phase: NA
-
Cholinergic Modulation of Condition and Emotion in Mood Disorders: Functional Neuroimaging Studies
NCT00055575 ·Status: TERMINATED ·Phase: PHASE2
-
Treatment for Cognitive Impairment in Depression
NCT04317001 ·Status: WITHDRAWN ·Phase: PHASE3
-
Repeated Neurocognitive Measurements in Depressed Patients
NCT05991232 ·Status: WITHDRAWN ·Phase: PHASE1/PHASE2