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Prediction Model of Response for CCRT in Esophageal Cancer

NCT03081988 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 140

Last updated 2023-10-04

No results posted yet for this study

Summary

1. Retrospective review of old patients

* Analysis of prediction factors for concomitant chemo-radiotherapy in locally advanced and advanced esophageal cancer from 2005 to 2015
2. Prospective case-control study: RNA sequencing \& miRNA microarray

* naive esophageal cancer patients who have a plan to receive concomitant chemo-radiotherapy

* acquirement of tissue, blood, clinical information
* isolation of RNA, DNA, serum database of clinical \& demographic information

\*\*\*Analysis of mRNA sequencing / miRNA sequencing\*\*\*\* first analysis of RNA sequencing: bioinformatician second analysis of RNA sequencing: principle investigator
3. Experimental set for qPCR (esophageal tissue) study group
4. TMA for screened exon gene
5. validation set for qPCR (esophageal tissue)
6. follow-up of circulating miRNA in blood (baseline blood \& post-CCRT blood 3M, 6M, 12M)
7. Prediction model for CCRT response in esophageal Cancer based on clinical and molecular factors
8. Validate the prediction model.

Conditions

  • Esophageal Cancer

Interventions

OTHER

chemoradiotherapy

concomitant chemoradiotherpay is routine treatment in locally advanced and advanced esophageal cancer and it is not for research.

Sponsors & Collaborators

  • Kyungpook National University Hospital

    lead OTHER

Principal Investigators

  • Su Youn Nam, MD, PhD · Kyungpook National University Medical Center

Eligibility

Min Age
40 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-10-19
Primary Completion
2024-12-31
Completion
2024-12-31

Countries

  • South Korea

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03081988 on ClinicalTrials.gov