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Interactions Between Neurostimulation and Physical Exercise

NCT03076632 · Status: WITHDRAWN · Phase: NA · Type: INTERVENTIONAL

Last updated 2017-09-28

No results posted yet for this study

Summary

* People with cervical spinal cord injury (SCI) and amyotrophic lateral sclerosis (ALS) have reduced connections in the nerve circuits between the brain and the hands. Activating spared nerve circuits is one potential way to improve recovery.
* The investigators are testing different combinations of physical wrist and hand movements paired with magnetic brain stimulation and electrical spinal cord or nerve stimulation to see the effects on nerve transmission to hand muscles.
* This is a preliminary study. This study is testing for temporary changes in nerve transmission to hand muscles. There is no expectation of long-term benefit from this study. If temporary changes are seen in this study, then future studies would focus on how to prolong that effect.

Conditions

Interventions

DEVICE

Cervical plus transcranial stimulation

Conditioning pulses of cervical electrical stimulation will be delivered before or after test pulses of transcranial magnetic stimulation.

DEVICE

Cervical stimulation plus hand/wrist exercise

Pulses of cervical stimulation will be delivered while the subject performs finger and wrist motor tasks.

DEVICE

Electromyographic (EMG)-triggered (closed-loop) stimulation

Force and EMG activity of specific hand muscles will be used to trigger peripheral nerve electrical stimulation or transcranial magnetic stimulation.

Sponsors & Collaborators

  • Bronx VA Medical Center

    lead FED

Principal Investigators

  • Noam Y. Harel, MD, PhD · James J. Peters VAMC

Study Design

Allocation
NON_RANDOMIZED
Purpose
DEVICE_FEASIBILITY
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
21 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-04-01
Primary Completion
2017-09-26
Completion
2017-09-26

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03076632 on ClinicalTrials.gov