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Graft Selection in Anatomic Anterior Cruciate Ligament Reconstruction

NCT03073083 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 439

Last updated 2025-11-25

No results posted yet for this study

Summary

A rupture of the anterior cruciate ligament (ACL) is a severe injury of the knee. The current gold Standard treatment for young and active patients with instability, is a surgical ACL reconstruction. However, there still is no consensus on which graft is best suited for this.The aim of the current multi-center randomized controlled trial was to investigate the hypothesis that an anatomic single bundle anterior cruciate ligament reconstruction with a (flat) quadriceps tendon autograft is at least as effective as reconstruction of the ruptured anterior cruciate ligament with a patella tendon autograft or a hamstringtendon autograft, in terms of failure, measured 2 years postoperatively. Failure is defined gedefinieerd as pathologicai laxity, complaints of knee instability in the absence of any pathological laxity and/or discontinuïty ofthe graft on MRl or arthroscopy.

Conditions

  • Anterior Cruciate Ligament Injuries

Interventions

PROCEDURE

Hamstring tendon autograft

ACL reconstruction surgery with hamstring tendon

PROCEDURE

Pattella tendon autograft

ACL reconstruction surgery with patella tendon

PROCEDURE

Quadriceps tendon autograft

ACL reconstruction surgery with quadriceps tendon

Sponsors & Collaborators

  • Martini Hospital Groningen

    collaborator OTHER

  • Gelderse Vallei Hospital

    collaborator OTHER

  • Orthopedisch Centrum Oost Nederland

    lead OTHER

Principal Investigators

  • R.A.G Hoogeslag, MD · OCON

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-03-06
Primary Completion
2031-12-31
Completion
2031-12-31

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03073083 on ClinicalTrials.gov