SpecTRA; A Study of the Validation of Protein Biomarkers in Transient Ischemic Attack

Summary

A clinical decision support rule/tool for classification of TIA/mimic that will enable rapid detection of ACVS in hyper-acute settings is being developed. Also under development is a multi-protein test using mass spectrometry (MS). This test will provide TIA results within an hour or two for a fraction of the price of neuroimaging. With guidance provided by this test at their disposal, physicians can inform patients whether they can go home safely or whether they need further testing. The right patients will receive the right treatment, reduce unwarranted imaging risks and costs, and reduce the burden of stroke. The Heart and Stroke Foundation will work to ensure that physicians, allied healthcare providers, the public and other stakeholders are aware of the outcomes and clinical impacts of this project.

Further, work is being done to establish the mechanisms to develop a strong phenotype for TIA that includes medical imaging (MRI), cardiac monitoring, cognitive assessments, and surveillance of health outcomes for extended periods of time.

Conditions

• TIA

Interventions

OTHER

Non-Interventional Study

This is a non-interventional study. However, several blood samples will be taken which would not be taken as part of standard of care.

Sponsors & Collaborators

• Genome Canada

  collaborator OTHER

• Genome British Columbia

  collaborator INDUSTRY

• Genome Alberta

  collaborator OTHER

• Vancouver Island Health Authority

  collaborator OTHER

• LifeLabs

  collaborator UNKNOWN

• Heart and Stroke Foundation of Canada

  collaborator OTHER

• Stroke Services BC

  collaborator UNKNOWN

• Bruker Daltonics

  collaborator INDUSTRY

• British Columbia Centre for Disease Control

  collaborator OTHER_GOV

• Andrew Penn

  lead OTHER

Principal Investigators

• Andrew M Penn, M.D. · Vancouver Island Health Authority

• Shelagh Coutts, M.D. · Alberta Health services

• Christoph Borchers, P.hD · UVic-Genome BC Proteomics Centre

Eligibility

Min Age

19 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2015-04-01

Primary Completion

2017-03-31

Completion

2017-03-31

Countries

• Canada

Study Locations