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Microbiota and the Lung Cancer

NCT03068663 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2026-03-20

No results posted yet for this study

Summary

The subject is to study the lung microbiota and the one of upper airways (UAs) (much less studied than the intestinal microbiota) in 40 patients having lung cancer. 20 patients undergo only surgical treatment, while other half receives also chemotherapy. The idea is to explore changes in microbiota of the lung, upper UAs and intestine, and potentially find associations between them. These results will serve us as a base for the future study, focused on manipulation of the microbiota by prebiotics, probiotics or symbiotics and its effect on anti-cancer treatment tolerance and effectiveness.

Conditions

  • Non Small Cell Lung Cancer

Interventions

OTHER

Sampling

Patients will receive their standard treatments, surgery with/without chemotherapy. A patient intervention consists in taking samples of blood, saliva, faeces, lung/tumour tissue, and bronchoalveolar lavage fluid.

Sponsors & Collaborators

  • Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

    collaborator OTHER

  • Université d'Auvergne

    collaborator OTHER

  • GREENTECH SA

    collaborator UNKNOWN

  • Centre Jean Perrin

    lead OTHER

Principal Investigators

  • Marie-Paule Vasson, Pr · Equipe ECREIN, CLARA, CRNH Auvergne; INRA, UMR 1019.

  • Edith Filaire, Pr · CIAMS, Université Paris-Sud, Université Paris-Saclay, Université Orléans

  • Annick Bernalier-Donadille, Dr · Equipe MINHOS, UR 454 Microbiologie, INRA

  • Rea Bingula, Ph.D. · Equipe ECREIN, CLARA, CRNH Auvergne; INRA, UMR 1019

  • Marc Filaire, MD, Pr · Service de Chirurgie Thoracique, Centre Jean Perrin

Study Design

Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-05-23
Primary Completion
2029-10-30
Completion
2029-10-30

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03068663 on ClinicalTrials.gov