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Therapeutic Hypothermia and eArly Waking

NCT03065946 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2020-12-22

No results posted yet for this study

Summary

Unconscious survivors of cardiac arrest who are treated with intravenous therapeutic hypothermia for 24 hours will be assessed after 12 hours for appropriateness to be woken early and extubated whilst continuing to receive therapeutic hypothermia. Sedation will be reduced/stopped at 12 hours to enable a comprehensive neurological assessment utilising a multimodal approach.

Providing the patient is clinically stable with no adverse neurological signs the patient will be extubated. Patients who remain unconscious will be reviewed 6 hourly for neurological recovery and their suitability to be extubated in line with standard practice.

Conditions

  • Out of Hospital Cardiac Arrest
  • Brain Injury

Interventions

OTHER

Early wakening

By using an intravascular device to administer mild TH for 24 hours, patients can safely have their medically induced coma reversed early at 12 hours, allowing an accurate neurological assessment to be performed

Sponsors & Collaborators

  • Mid and South Essex NHS Foundation Trust

    lead OTHER

Principal Investigators

  • Thomas Keeble, MBBS MD MRCP · Basildon and Thurrock University Hospitals NHS FT

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-02-10
Primary Completion
2018-02-28
Completion
2018-02-28

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03065946 on ClinicalTrials.gov