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Influence of Statins in Artery Aneurysms

NCT03061487 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2017-02-27

No results posted yet for this study

Summary

The altered balance between the proteinases and their tissue inhibitors (TIMPS) is one of the pathogenetical mechanism of the aneurysmatic connective tissue degeneration. The increasement of protease, collagenase and elastase activity results indeed in a dramatic drop of collagen and elastin tissue and serum levels.Matrix Metalloproteinases (MMPs) are a group of proteolytic enzymes that along with their specific and non-specific inhibitors modulate the extracellular matrix composition. Recent studies have suggested an interesting role of microRNAs (miRNAs) in the regulation mechanisms of inflammation.

The aim of our study is to analyse the influence of statin treatment on aneurysmatic disease by monitoring MMPs and miRNAs in aneurysmatic wall tissue and MMps blood levels.

Conditions

  • Statin
  • Aneurysm
  • Extracellular Matrix Alteration

Interventions

PROCEDURE

Open Surgical Treatment of Aneurysm (Aneurysmectomy)

Aneurysmectomy is a surgical procedure in which a localized, dilated, weakened section of an artery (aneurysm) is removed (resected). The artery is either replaced with a synthetic graft, as seen in an aneurysm in the chest (thoracic aneurysm), abdomen (abdominal aneurysm) or leg (femoral or popliteal aneurysm).

Sponsors & Collaborators

  • University of Catanzaro

    lead OTHER

Principal Investigators

  • Stefano de Franciscis, M.D. · University Magna Graecia of Catanzaro

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-02-15
Primary Completion
2018-02-26
Completion
2018-04-27

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03061487 on ClinicalTrials.gov