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The Change of Tissue Oxygen Saturation Following Volatile Anesthesia

NCT03060798 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2020-04-14

No results posted yet for this study

Summary

General anesthesia can affect tissue oxygen saturation and microcirculatory reactivity. However, the differences in microcirculation caused by anesthetic methods have not been well studied. Near-infrared spectroscopy (NIRS) measures peripheral tissue oxygen saturation noninvasively and can be used in conjunction with vascular occlusion (VOT) experiments. The purpose of this study was to examine the changes in NIRS derived tissue oxygen saturation (StO2) and microcirculatory reactivity by VOT after inhalation anesthesia in healthy population.

This prospective, observational study will be performed on 60 healthy patients who had undergone elective surgery under volatile general anesthesia. The investigators measure StO2 and microvascular reactivity using NIRS combined with vascular occlusion test (VOT). The parameters were performed twice per patient, before and after the induction of anesthesia.

Occlusion slope and recovery slope during VOT will be compared before and after anesthesia. Moreover, the changes depend on the age will be analyzed.

Conditions

  • Healthy
  • Aging

Interventions

DRUG

Desflurane

general anesthesia using desflurane.

DEVICE

Near-infrared spectroscopy monitor

tissue oxygen saturation monitoring combined with vessel occlusion test

Sponsors & Collaborators

  • Pusan National University Hospital

    lead OTHER

Principal Investigators

  • Hyeon-Jeong Lee, PhD · Pusan National University Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-08-02
Primary Completion
2017-12-31
Completion
2017-12-31
FDA Drug
Yes
FDA Device
Yes

Countries

  • South Korea

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03060798 on ClinicalTrials.gov