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Effect of Hypotensive Anesthesia on the Perfusion Index

NCT03059316 · Status: COMPLETED · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2019-03-29

No results posted yet for this study

Summary

Controlled hypotension has been used as a mean of reducing intraoperative blood loss and better visualization of the surgical field in nasal surgeries. Perfusion index has been considered a useful tool for monitoring changes in peripheral perfusion using Masimo set and serum lactate for central perfusion. Many medications were used to induce hypotension. In this study we will compare the effects of tridil and labetalol on the perfusion.

Conditions

  • Controlled Hypotension for Nasal Surgeries

Interventions

COMBINATION_PRODUCT

Massimo device

Massimo is a newly introduced device which can measure the peripheral organ perfusion and expressed it as perfusion index(PI).

DRUG

Nitroglycerin drug

Nitroglycerin is a drug used as an hypotensive agent through its vasodilation effect on veins

DRUG

Labetalol

Labetalol is an antagonist of adrenergic receptors (a1, b1, b2) which is used as an hypotensive inducer. This drug targets the beta receptors 5 to 10 times more specific than alpha receptors so that minor tachycardia happens

Sponsors & Collaborators

  • Cairo University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Model
SEQUENTIAL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-06-10
Primary Completion
2017-04-10
Completion
2017-04-21

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03059316 on ClinicalTrials.gov