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Diagnosis of Lynch Syndrome Based on Next-generation Sequencing in Colorectal Cancer

NCT03047226 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 311

Last updated 2021-07-15

No results posted yet for this study

Summary

The purpose of this study is to determine the proportion of patients diagnosed with Lynch syndrome in colorectal cancer patients with the loss of staining by immunohistochemistry (IHC) of any of the mismatch repair (MMR) proteins. Besides, this study aims to test the specificity and the sensitivity of detecting microsatellite instability (MSI) by next-generation sequencing, and to find out the consistency between IHC and MSI in colorectal cancer patients in China. In addition, researchers want to analyze the clinical characteristics and germline mutation of Lynch syndrome in Chinese population.

Conditions

Interventions

OTHER

next-generation sequencing

Use next-generation sequencing to test germline mutation and microsatellite instability.

Sponsors & Collaborators

  • Guangzhou Burning Rock Medical Examination Institute Co., Ltd.

    collaborator INDUSTRY

  • Second Affiliated Hospital, School of Medicine, Zhejiang University

    lead OTHER

Principal Investigators

  • Ying Yuan, MD · Second Affiliated Hospital, School of Medicine, Zhejiang University

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-02-28
Primary Completion
2018-07-31
Completion
2018-07-31

Countries

  • China

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03047226 on ClinicalTrials.gov