Avelumab in Relapsed and Refractory Peripheral T-cell Lymphoma
NCT03046953 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 35
Last updated 2024-07-16
Summary
The AVAIL-T trial is a trial to find out how effective avelumab is at treating patients with primary T-cell lymphoma that is refractory to or has relapsed following initial treatment.
Conditions
- T-Cell Lymphoma Relapsed
- T-Cell Lymphoma Refractory
Interventions
- DRUG
-
Avelumab
anti-PDL1 antibody
Sponsors & Collaborators
-
Bloodwise
collaborator OTHER - collaborator INDUSTRY
-
University of Birmingham
lead OTHER
Principal Investigators
-
Simon Wagner, MD · Univeristy of Leicester
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 16 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2017-12-08
- Primary Completion
- 2020-07-31
- Completion
- 2021-07-27
Countries
- United Kingdom
Study Locations
More Related Trials
-
Study of VELCADE and Rituximab in Patients With Relapsed or Refractory B-cell Non-Hodgkin's Lymphoma
NCT00312845 ·Status: COMPLETED ·Phase: PHASE3
-
Avelumab In Patients With Previously Treated Advanced Stage Classical Hodgkin's Lymphoma (JAVELIN HODGKINS)
NCT02603419 ·Status: TERMINATED ·Phase: PHASE1
-
Nivolumab in Treating Patients With Relapsed or Refractory Peripheral T-cell Lymphoma
NCT03075553 ·Status: TERMINATED ·Phase: PHASE2
-
Phase I/II Trial of VELCADE Plus Zevalin in Patients With Relapsed or Refractory Follicular Lymphoma
NCT00372905 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Avelumab in the Frontline Treatment of Advanced Classical Hodgkin Lymphoma - a Window Study
NCT03617666 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Pilot Study to Investigate the Safety and Clinical Activity of Avelumab (MSB0010718C) in Thymoma and Thymic Carcinoma After Progression on Platinum-Based Chemotherapy
NCT03076554 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Testing the Addition of Duvelisib or CC-486 to the Usual Treatment for Peripheral T-Cell Lymphoma
NCT04803201 ·Status: SUSPENDED ·Phase: PHASE2
-
Pembrolizumab and Brentuximab Vedotin in Subjects With Relapsed/Refractory T-cell Lymphoma
NCT05313243 ·Status: RECRUITING ·Phase: PHASE2
-
Bortezomib in Treating Patients With Relapsed or Refractory Cutaneous T-Cell Lymphoma
NCT00182637 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase Ib Study to Evaluate the Safety, Tolerability, and Pharmacokinetics (PK) of Avelumab in Combination With M9241(NHS-IL12) (JAVELIN IL-12)
NCT02994953 ·Status: TERMINATED ·Phase: PHASE1
-
Avelumab, Utomilumab, Rituximab, Ibrutinib, and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma or Mantle Cell Lymphoma
NCT03440567 ·Status: COMPLETED ·Phase: PHASE1
-
Avelumab, Utomilumab, Anti-OX40 Antibody PF-04518600, and Radiation Therapy in Treating Patients With Advanced Malignancies
NCT03217747 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
506U78 in Treating Patients With Recurrent or Refractory Cutaneous T-cell Lymphoma
NCT00005982 ·Status: TERMINATED ·Phase: PHASE2
-
Everolimus and Bortezomib in Treating Patients With Relapsed or Refractory Lymphoma
NCT00671112 ·Status: TERMINATED ·Phase: PHASE1
-
Nivolumab and Lenalidomide in Treating Patients With Relapsed or Refractory Non-Hodgkin or Hodgkin Lymphoma
NCT03015896 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
A Study of Ruxolitinib and Duvelisib in People With Lymphoma
NCT05010005 ·Status: RECRUITING ·Phase: PHASE1
-
Evaluation of the Combination of Romidepsin and Carfilzomib in Relapsed/Refractory Peripheral T Cell Lymphoma Patients
NCT03141203 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Alefacept in Treating Patients With Relapsed or Refractory Cutaneous T-Cell Lymphoma or Peripheral T-Cell Non-Hodgkin's Lymphoma
NCT00438802 ·Status: COMPLETED ·Phase: PHASE1
-
VELCADE® (Bortezomib) With Rituximab in Subjects With Relapsed or Refractory Indolent B-Cell Lymphoma
NCT00085696 ·Status: COMPLETED ·Phase: PHASE2
-
A Study in Participants Previously Enrolled in a Genentech- and/or F. Hoffmann-La Roche Ltd-Sponsored Atezolizumab Study (IMbrella A)
NCT03148418 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Durvalumab With or Without Lenalidomide in Treating Patients With Relapsed or Refractory Cutaneous or Peripheral T Cell Lymphoma
NCT03011814 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
A Platform Trial Evaluating New Drugs or Combination in R/R Peripheral T-cell Lymphomas
NCT07018752 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Avastin Plus Rituximab for Patients With B-Cell Non-Hodgkin's Lymphoma
NCT00081861 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of Atezolizumab in Combination With an Immunotherapy Agent Investigated With or Without Anti-Cd20 Therapy in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma
NCT03369964 ·Status: WITHDRAWN ·Phase: PHASE1
-
Adding Targeted Drugs to Usual Chemotherapy for Adults With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LBL)
NCT06210750 ·Status: WITHDRAWN ·Phase: PHASE2