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The Influence of the Microbiome on Rotavirus Vaccine Immunogenic Response in Infants in Karachi, Pakistan

NCT03031743 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 88

Last updated 2017-01-26

No results posted yet for this study

Summary

This is a nested case-control study within an ongoing rotavirus vaccine immunogenicity trial in Karachi, Pakistan. The primary study aim is to compare the fecal microbiota composition and diversity of infants who do (control) and do not (case) demonstrate immune seroconversion to rotavirus vaccination. The infants will be matched for vaccination dose, age and breast-feeding practices.

Conditions

  • Rotavirus

Sponsors & Collaborators

  • Aga Khan University

    collaborator OTHER

  • Wageningen University

    collaborator OTHER

  • University of Padova

    collaborator OTHER

  • Centers for Disease Control and Prevention

    collaborator FED

  • Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

    lead OTHER

Principal Investigators

  • Vanessa C Harris, MD · Amsterdam Institute for Global Health and Development; Academic Medical Center, Amsterdam

Eligibility

Min Age
6 Weeks
Max Age
3 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-01-31
Primary Completion
2015-02-28
Completion
2015-07-31

Countries

  • Pakistan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03031743 on ClinicalTrials.gov