Efficacy of Betalactam Antibiotics in Prolonged Infusion Compared to Intermittent in Pediatric Patients With Sepsis

Summary

This study evaluates the efficacy and safety of the administration of betalactam antibiotics in prolonged infusion compared to intermittent infusion in children with sepsis. Half of participants will receive piperacillin/tazobactam, imipenem or meropenem in continuous or extended infusion, while the other half will receive piperacillin/tazobactam, imipenem or meropenem in intermittent infusion.

Conditions

• Sepsis

Interventions

DRUG

Intermittent Piperacillin/tazobactam

Piperacillin/tazobactam administered in 30 minutes infusion.

DRUG

Continuous Piperacillin/tazobactam

Piperacillin/tazobactam administered in 24 hours infusion.

DRUG

Intermittent Imipenem

Imipenem administered in 60 minutes infusion.

DRUG

Extended Imipenem

Imipenem administered in 6 hours infusion.

DRUG

Intermittent Meropenem

Meropenem administered in 60 minutes infusion.

DRUG

Extended Meropenem

Meropenem administered in 8 hours infusion.

Sponsors & Collaborators

• Instituto Mexicano del Seguro Social

  collaborator OTHER_GOV

• Hospital Infantil de Mexico Federico Gomez

  collaborator OTHER

• Hospital Regional de Alta Especialidad del Bajio

  collaborator OTHER

• Coordinación de Investigación en Salud, Mexico

  lead OTHER_GOV

Principal Investigators

• Yazmín del Carmen Fuentes · Instituto Mexicano del Seguro Social

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

1 Month

Max Age

17 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-02-01

Primary Completion

2019-12-30

Completion

2020-01-30

Countries

• Mexico

Study Locations