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Sperm DNA Damage in β-thalassemia Major: Is There a Role for Antioxidants?

NCT03014882 · Status: UNKNOWN · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2017-01-09

No results posted yet for this study

Summary

Accumulation of iron in patients with beta thalassemia major causes free radical formation which leads to damage of biological membranes. Sperm DNA damage may result from these generated antioxidants.

We aimed at investigating the current DNA damage in the sperms of adult patients with beta thalassemia major and the effect generated by giving antioxidant treatment for 6 months.

Conditions

  • Endocrine Disease
  • Fertility Decreased Male
  • DNA Damage

Interventions

DRUG

L-Carnitine and N-acetyl cysteine

Sponsors & Collaborators

  • Ain Shams University

    lead OTHER

Principal Investigators

  • Heba H Elsedfy, Professor · Ain Shams University

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
16 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-02-28
Primary Completion
2017-12-31
Completion
2017-12-31

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03014882 on ClinicalTrials.gov