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Comparative Study of Circulating microRNA Changes in Patients With Liver Injury and Healthy Subjects

NCT03000621 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2017-05-30

No results posted yet for this study

Summary

The objectives are to:

1. validate a panel of tissue-specific miRNAs that are differentially expressed in the plasma of patients with and without liver injuries
2. investigate the physiological range of the circulating miRNA panel in Healthy Subjects and under stress
3. investigate the dysregulation of circulating miRNA panel and their prognostic and predictive values in clinical outcomes in identifying patients at high risk for mortality and acute liver failure.

This trial involves peripheral blood sampling from subjects at their earliest presentation and remaining stays in the hospitalization in the emergency department. The investigators will develop panels of miRNAs that are specific indicator of early onset of major organ failures, and correlate clinical outcomes with these miRNAs.

Conditions

  • Drug-Induced Liver Injury
  • Liver Failure

Sponsors & Collaborators

  • Chengdu Nuoen Biotechnologies, Inc.

    collaborator OTHER

  • Sichuan Cancer Hospital and Research Institute

    collaborator OTHER

  • University of Electronic Science and Technology of China

    lead OTHER

Principal Investigators

  • Huang Jian, PhD · University of Electronic Science and Technology of China

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-12-31
Primary Completion
2018-12-31
Completion
2019-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03000621 on ClinicalTrials.gov