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RELVAR Effects on Parasternal Muscle Activity, Diaphragm, and Ventilation in Severe COPD

NCT02989935 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2025-02-18

No results posted yet for this study

Summary

This study examines the effect of the ultra long acting beta agonist/corticosteroid bronchodilator combination fluticasone furoate/vilanterol trifenatate, on respiratory muscles and ventilation in adults with severe bronchitis or emphysema (COPD).

Conditions

Interventions

PROCEDURE

Ventilation

Measurements of ventilation with subjects seated, and breathing across a pneumotachygraph and pressure transducer to measure inspiratory airflow, during both resting and CO2 stimulated breathing.

PROCEDURE

Parasternal EMG

Recordings of electrical activity (EMG) from the parasternal intercostal muscle in the second intercostal space on the upper anterior chest wall adjacent to the sternum.

PROCEDURE

Phrenic magnetic stimulation

Bilateral maximal magnetic stimulation (Magstim) of the phrenic nerves.

Sponsors & Collaborators

  • University of Calgary

    lead OTHER

Principal Investigators

  • Paul A Easton, MD, PhD · University of Calgary

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-04-30
Primary Completion
2026-03-31
Completion
2026-07-01

Countries

  • Canada

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02989935 on ClinicalTrials.gov