Systematic Search for Primary Immunodeficiency in Adults With Infections

Summary

Antibody deficiencies and complement deficiencies are the most frequent Primary immunodeficiencies (PIDs) in adults, and are associated with greatly increased susceptibility to recurrent and/or severe bacterial infections - especially upper and lower respiratory tract infections and meningitis. The literature data suggest that PIDs are under-diagnosed in adults. The current European and US guidelines advocate screening adults for PIDs if they present recurrent benign especially upper and lower respiratory tract infections, or if they have experienced at least two severe bacterial infections and/or have a recurrent need for intravenous antibiotics. The objective of the demonstrate the interest of PIDs screening in adult patients who present such recurrent infections and/or after the first severe bacterial infection, especially when the patients do not present with known, etiologically relevant comorbidities.

Conditions

• Complement Deficiency
• Antibody Deficiency
• Chronic Sinus Infection
• Meningitis, Bacterial
• Pneumonia, Bacterial
• Otitis Media
• Streptococcal Infection
• Neisseria Infections
• Haemophilus Influenza
• Pneumococcal Infections

Interventions

BIOLOGICAL

Immunological diagnosis tests

(Non exhaustive list): hemogram, IgG, A, M, IgG subclasses, complement, vaccinal response to protein and polysaccharide antigens, ...

Sponsors & Collaborators

• Imagine Institute

  collaborator OTHER

• Octapharma

  collaborator INDUSTRY

• CSL Behring

  collaborator INDUSTRY

• Laboratoire français de Fractionnement et de Biotechnologies

  collaborator INDUSTRY

• Air Liquide SA

  collaborator INDUSTRY

• The Binding Site Ltd

  collaborator UNKNOWN

• University Hospital, Lille

  lead OTHER

Principal Investigators

• Guillaume Lefevre, MD · University Hospital, Lille

Study Design

Allocation

NA

Purpose

DIAGNOSTIC

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2015-03-31

Primary Completion

2020-03-31

Completion

2020-03-31

Countries

• France

Study Locations