Risk Evaluation and Education for Alzheimer's Disease - the Study of Communicating Amyloid Neuroimaging (REVEAL-SCAN)

Summary

This study is intended to examine the impact of learning amyloid brain imaging results among asymptomatic older adults, and how to safely communicate these results and educate on the risk of developing Alzheimer's disease.

Conditions

• Alzheimer Disease
• Amyloid Beta-Peptides
• Risk Assessment
• Education
• Neuropsychological Tests
• Neuroimaging

Interventions

BEHAVIORAL

Alzheimer's Disease Risk Disclosure

Subjects will learn a numerical risk estimate for the chance of progressing to dementia of the Alzheimer's type.

BEHAVIORAL

Amyloid Brain Imaging and Alzheimer's Disease Risk Disclosure

Subjects will learn their own "elevated" or "not elevated" amyloid results and a numerical risk estimate for the chance of progressing to dementia of the Alzheimer's type.

Sponsors & Collaborators

• University of Pennsylvania

  collaborator OTHER

• University of Michigan

  collaborator OTHER

• Duke University

  collaborator OTHER

• Boston University

  collaborator OTHER

• National Institute on Aging (NIA)

  collaborator NIH

• Brigham and Women's Hospital

  lead OTHER

Principal Investigators

• Robert C Green, MD, MPH · Brigham and Women's Hospital

• Jason Karlawish, MD · University of Pennsylvania

• J. Scott Roberts, PhD · University of Michigan

• Kathleen Welsh-Boomer, PhD · Duke University

Study Design

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Model

CROSSOVER

Eligibility

Min Age

65 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2016-11-30

Primary Completion

2020-05-13

Completion

2021-04-29

Countries

• United States

Study Locations