Multicenter Cohort Study on Osteoporosis

Summary

This is a multicenter cohort study on osteoporosis in nine cities of China which locate in the east, south, north, west, middle of China. At least 3000 middle-aged and elderly permanent residents (women aged from 45 to 79, and men aged from 50 to 79) in every city will be enrolled. Residents with severe mental diseases, physical diseases or acute infectious diseases who could not cooperate with the survey as well as lactating or pregnant women were excluded. All the enrolled residents who signed informed consent will finish questionnaire including demographic characteristics, history of smoking, alcohol drinking, falls and fracture, family genetic history, chronic diseases and medicine,diary and physical practice，stool and urine status. Osteoporosis risk, health status, constitution of traditional Chinese medicine (TCM),symptoms of kidney yang deficiency in TCM，living environment,sweating status will be evaluated. Fasting blood glucose test and other blood tests for liver and kidney function,bone metabolism，vitamins，vitamin D metabolism and transportation as well as calcium and phosphate metabolism, will be performed. Bone mineral density and physical examinations (height, weight, waist circumference, hip circumference,grip,sit-to-stand test, tongue coating and pulse) will also be performed at enrollment and every two years after enrollment. DNA of blood cells will be preserved for specific study such as SNP analyses.Tongue coating and feces will be preserved for microflora analyses.

Conditions

• Osteoporosis

Sponsors & Collaborators

• Wangjing Hospital, China Academy of Chinese Medical Sciences

  collaborator OTHER

• Dongzhimen Hospital, Beijing

  collaborator OTHER

• The First Affiliated Hospital of Guangzhou University of TCM

  collaborator UNKNOWN

• Guangdong Provincial Hospital of Traditional Chinese Medicine

  collaborator OTHER

• Affiliated Hospital of Changchun University of Chinese Medicine

  collaborator OTHER

• Gansu Provincial Hospital

  collaborator OTHER

• Guangzhou Kingmed Diagnostics Co., Ltd.

  collaborator UNKNOWN

• Affiliated Hospital of Shandong University of Traditional Chinese Medicine

  collaborator OTHER

• Yunnan Provincial Hospital of Traditional Chinese Medicine

  collaborator UNKNOWN

• Shenzhen Pingle Orthopedic Hospital

  collaborator UNKNOWN

• First People's Hospital of Nankang District, Ganzhou City

  collaborator UNKNOWN

• Shanghai University of Traditional Chinese Medicine

  lead OTHER

Principal Investigators

• Yongjun Wang · Shanhgai University of TCM

Eligibility

Min Age

45 Years

Max Age

79 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2016-11-30

Primary Completion

2026-10-31

Completion

2028-10-31

Countries

• China

Study Locations