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Interaction of Bexagliflozin With Metformin, Glimepiride and Sitagliptin

NCT02956044 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 54

Last updated 2021-07-22

Study results available
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Summary

The purpose of this study is to examine the drug-drug interaction in your body when given the study drug, bexagliflozin, with three commonly used ant-diabetic medications, metformin, glimepiride or sitagliptin. The study will also evaluate how safe the study drug is and how well the study drug is tolerated when taken with metformin, glimepiride or sitagliptin.

Conditions

  • Type2 Diabetes Mellitus

Interventions

DRUG

Bexagliflozin

Bexagliflozin tablets, 20 mg

DRUG

Metformin

1000 mg metformin

DRUG

Glimepiride

4 mg glimepiride

DRUG

Sitagliptin

100 mg sitagliptin

Sponsors & Collaborators

  • Theracos

    lead INDUSTRY

Principal Investigators

  • Mason Freeman, M.D. · Massachusetts General Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-11-30
Primary Completion
2017-03-31
Completion
2017-03-31
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02956044 on ClinicalTrials.gov