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Testing if BCG (Bacille Calmette-Guérin) Vaccination Can Induce Innate Immune Training in Adult People Above 50 Years of Age in Guinea-Bissau

NCT02953327 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2021-04-26

No results posted yet for this study

Summary

The propose is to test innate immune training in a pilot study of 40 adults \>50 years of age people in Guinea-Bissau. The hypothesis is that BCG vaccination will be associated with increased innate immune training measured as increased cytokine release after in vitro Peripheral Blood Mononuclear Cells (PBMC) stimulation with e.g. Mycobacterium Tuberculosis, Staphylococcus Aureus, Candida Albicans and Streptococcus Pneumoniae.

Conditions

  • Innate Immunity
  • Bacille Calmette-Guérin

Interventions

BIOLOGICAL

Bacille Calmette-Guerin

Vaccine against tuberculosis

BIOLOGICAL

BCG solvent

Simple solvent

Sponsors & Collaborators

  • Radboud University Medical Center

    collaborator OTHER

  • Bandim Health Project

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-02-01
Primary Completion
2017-06-15
Completion
2020-06-15

Countries

  • Guinea-Bissau

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02953327 on ClinicalTrials.gov