Adipose Tissue Function and Response to Exercise Training in Women With and Without Polycystic Ovary Syndrome

Summary

The primary aim of this trial is to investigate adipose tissue function in women with and without polycystic ovary syndrome (PCOS). PCOS is a common endocrine disorder in young women. The pathogenesis behind PCOS is complex and only partly understood, and deeper mechanistic insight is needed. Insulin resistance is a central feature of PCOS, and recent studies have suggested that this is linked to aberrant adipose tissue function. Exercise training has been found to improve the symptoms in PCOS, but we need more knowledge about why. While processes involved in skeletal muscle oxidative remodeling are well described, it is to a large extent unknown whether the oxidative capacity of human adipose tissue is modified by endurance training. The women included in this study will be matched (for body mass index, body weight, and age) to participants in another study. This will enable the investigators to do a comparison between cases (women with PCOS) and controls (women without PCOS) at baseline, and to assess the responses to exercise training in adipose tissue.

Conditions

• Polycystic Ovary Syndrome

Interventions

BEHAVIORAL

4x4 minutes high intensity interval training

Treadmill running/walking with 10 minutes warm-up at 60-70% of maximum heart rate, 4x4 minute intervals at 90-95% of maximum heart rate separated by 3-minutes active pauses at 60-70% of maximum heart rate, and 3 minutes cool-down.

BEHAVIORAL

10x1 minute high intensity interval training

Treadmill running/walking with 10 minutes warm-up at 60-70% of maximum heart rate, ten 1-minute intervals at maximal intensity (that can be performed for one minute), separated by 1-minutes active pauses at 60-70% of maximum heart rate, and 3 minutes cool-down.

Sponsors & Collaborators

• St. Olavs Hospital

  collaborator OTHER

• Liverpool John Moores University

  collaborator OTHER

• Australian Catholic University

  collaborator OTHER

• Norwegian University of Science and Technology

  lead OTHER

Principal Investigators

• Jorunn L Helbostad, phd prof · Norwegian University of Science and Technology

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

45 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2016-10-24

Primary Completion

2022-01-31

Completion

2022-01-31

Countries

• Australia
• Norway

Study Locations