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Sickle Cell Anemia and Cerebral Microcirculation : Multimodal Exploration

NCT02909283 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 64

Last updated 2018-11-14

No results posted yet for this study

Summary

The aim of this study is to evaluate determinants of cerebral oxygenation and perfusion at the microcirculatory level in children with sickle cell anemia (SCA) using combined novel investigational tools: Arterial Spin Labeling (ASL) perfusion MR (Magnetic Resonnance) imaging, brain Near Infra-Red Spectroscopy (NIRS) and red blood cell (RBC) rheological properties.

Conditions

Interventions

PROCEDURE

Physical exams and blood analyzes

Blood samples collection (for DNA, plasma and cells analyzes) ; Hemorheologic analyzes ; ASL sequence on MRI ; Near Infra Red Spectroscopy (NIRS) and associated cardiofrequency analyze.

Sponsors & Collaborators

  • Hopital Universitaire Robert-Debre

    collaborator OTHER

  • Imagine Institute

    lead OTHER

Principal Investigators

  • Valentine Boursse · Hôpital Necker-Enfants Malades

  • Suzanne Verlhac · Centre Hospitalier intercommunal de Créteil

Eligibility

Min Age
6 Years
Max Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-03-02
Primary Completion
2017-07-11
Completion
2017-07-11

Countries

  • France

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02909283 on ClinicalTrials.gov