A Phase 2 Trial of IW-1973, A Stimulator of Soluble Guanylate Cyclase (sGC), in Patients With Stable Type 2 Diabetes and Hypertension
NCT02906579 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 11
Last updated 2020-04-16
Summary
To evaluate the impact of escalating doses of IW-1973 on endothelial function \[using EndoPAT to measure fingertip small vessel pulse volume\], blood pressure (BP), and heart rate.
Conditions
- Diabetes Mellitus, Type 2
- Hypertension
Interventions
- DRUG
-
Matching Placebo
- DRUG
-
IW-1973
Sponsors & Collaborators
-
Cyclerion Therapeutics
lead INDUSTRY
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 30 Years
- Max Age
- 65 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2016-09-30
- Primary Completion
- 2017-03-17
- Completion
- 2017-03-17
Countries
- United States
Study Locations
More Related Trials
-
Dose-Ranging Study In Subjects With Type 2 Diabetes Mellitus Who Are Treatment-Naive
NCT00495469 ·Status: COMPLETED ·Phase: PHASE2
-
Investigation on Safety, Tolerability, and Pharmacokinetics of Single Doses of NNC0113-0987 in Healthy Male Subjects
NCT01690169 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Test How SB756050 Affects Subjects With Type 2 Diabetes Mellitus After 6 Days of Dosing.
NCT00733577 ·Status: COMPLETED ·Phase: PHASE1
-
To Assess Safety, Tolerability, Pharmacokinetics/Pharmacodynamics and the Effect of Fasting After Single Oral Doses of AZD5658 in Type 2 Diabetes
NCT01176097 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Evaluate Cardiovascular Outcomes in Patients With Type 2 Diabetes Treated With ITCA 650
NCT01455896 ·Status: COMPLETED ·Phase: PHASE3
-
Second-line Therapies for Patients With Type 2 Diabetes and Moderate Cardiovascular Disease Risk
NCT05214573 ·Status: COMPLETED
-
A Study of the Safety, Pharmacokinetics, and Pharmacodynamics of CNTO 3649 in Healthy Adults and Patients With Type 2 Diabetes Mellitus
NCT00882726 ·Status: COMPLETED ·Phase: PHASE1
-
Single and Multiple Ascending Doses of MEDI6570 in Subjects With Type 2 Diabetes Mellitus
NCT03654313 ·Status: COMPLETED ·Phase: PHASE1
-
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BI 1356 BS in Patients With Type 2 Diabetes
NCT02183350 ·Status: COMPLETED ·Phase: PHASE1
-
A First-time-in-human Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Ascending Doses of GSK189075A in Healthy Subjects and in Subjects With Type 2 Diabetes Mellitus
NCT01571661 ·Status: COMPLETED ·Phase: PHASE1
-
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BI 1356 BS as Tablet in Patients With Type 2 Diabetes
NCT02183415 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Evaluate ITCA 650 for the Treatment of Type 2 Diabetes
NCT01455857 ·Status: COMPLETED ·Phase: PHASE3
-
A Two-Part, Single Ascending Dose Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of DS-7309 in Healthy Volunteers and Subjects With Type 2 Diabetes Mellitus
NCT01862939 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase 2 Study of Cyclo-Z in Subjects With Type 2 Diabetes
NCT03560271 ·Status: COMPLETED ·Phase: PHASE2
-
Randomized, Placebo-controlled, 2 Period, Single-blind, Sequential, Multiple Ascending Dose Study
NCT01956305 ·Status: COMPLETED ·Phase: PHASE1
-
First Research Study of the Possible New Medicine NNC0113-2023 in Healthy Men.
NCT03617081 ·Status: COMPLETED ·Phase: PHASE1
-
The Efficacy and Safety of Different Doses of SY-009 in Patients With Type 2 Diabetes Mellitus
NCT05426018 ·Status: UNKNOWN ·Phase: PHASE2
-
Study to Evaluate Safety and PK/PD of DA-3091 in Healthy Male Subjects
NCT01156779 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MK8245 (8245-004)(COMPLETED)
NCT00790556 ·Status: COMPLETED ·Phase: PHASE1
-
Molecular Mechanisms of Type 2 Diabetes Mellitus
NCT00816218 ·Status: COMPLETED ·Phase: PHASE4
-
Safety and Tolerability After Four Weeks of Treatment With AZD1656 in Patients With Type 2 Diabetes
NCT00856908 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GSK1362885 in Type 2 Diabetics
NCT01013766 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Evaluate the Pharmacokinetics and Safety Between Single Oral Administration of BR3006 and Co-administration of BR3006A, BR3006B and BR3006C in Healthy Adult Volunteers Under Fed Conditions
NCT06890299 ·Status: COMPLETED ·Phase: PHASE1
-
A Research Study of a New Medicine NNC0519-0130 in Japanese and Non-Japanese Men
NCT05870670 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Assess Safety, Tolerability and Pharmacokinetics of GLPG2737 in Healthy Subjects
NCT03410979 ·Status: COMPLETED ·Phase: PHASE1