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Blood-brain Barrier Permeability Study in Adults With Meningitis

NCT02902588 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2018-10-18

No results posted yet for this study

Summary

The purpose of the study is to confirm the applicability and usefulness of the novel method of assessment of the permeability of the blood-brain barrier and in monitoring of the treatment of patients with meningitis. The proposed technique is based on evaluation of the kinetics of the indocyanine green (ICG) outflow from the brain with the use of near-infrared spectroscopy (NIRS). Usefulness of the NIRS-based method will be analyzed in relation to the reference method, which is contrast-enhanced magnetic resonance imaging (MRI).

Conditions

  • Blood-Brain Barrier Permeability

Interventions

OTHER

ICG-PULSION

Intravenous administration of indocyanine green

DEVICE

LiMON, Pulsion Medical Systems

Application of near infrared light

OTHER

Gadolinium (Gadovist, Bayer, Germany)

Injection of gadolinium

Sponsors & Collaborators

  • Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences

    lead OTHER

Principal Investigators

  • Adam Liebert, Prof. · Nalecz Institute of Biocybernetics and Biomedical Engineering Polish Academy of Science

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
FACTORIAL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-08-01
Primary Completion
2018-01-31
Completion
2018-01-31

Countries

  • Poland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02902588 on ClinicalTrials.gov