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KERatoconus and Metalloproteinases InvesTigation

NCT02891655 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 23

Last updated 2020-12-10

No results posted yet for this study

Summary

Corneal stromal thinning observed in keratoconic eyes could result from an increased synthesis of MMP at the level of the anterior stroma and the corneal epithelium induced by an overexpression of the Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) and Galectin-3 by epithelial cells. A differential expression of EMMPRIN, Galectin-3 and metalloproteinases (MMP) may be observed between the apex of the keratoconus and the peripheral cornea. Highlighting the implication of EMMPRIN and Galectin-3 could lead to the development of specific inhibitors to slow or to stop keratoconus evolution.

Conditions

  • Keratoconus

Interventions

OTHER

immuno-histo-chemical analysis

in vitro immuno-histo-chemical analysis of corneal epithelium

Sponsors & Collaborators

  • Fondation Ophtalmologique Adolphe de Rothschild

    lead NETWORK

Principal Investigators

  • Eric GABISON, MD, PhD · Fondation OPH A de Rothschild

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-12-02
Primary Completion
2020-06-26
Completion
2020-11-26

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02891655 on ClinicalTrials.gov