Regulatory B Cells and Chronic Immune Thrombocytopenia
NCT02891109 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 36
Last updated 2016-09-07
Summary
The chronic immune thrombopenia is an autoimmune disease caused by B cells. These cells produce anti platelets and megakaryocytes antibodies. Some B cells, named regulatory B cells, are known to control other cells. Their action in chronic immune thrombopenia is actually unknown.
Conditions
- Purpura, Thrombocytopenic, Idiopathic
- Regulatory B Cells
Interventions
- BIOLOGICAL
-
Biological tests
From the blood: B and T cells extraction then co-culture B and T cells and characterization of lymphocytes by flow cytometry
Sponsors & Collaborators
-
University Hospital, Brest
lead OTHER
Principal Investigators
-
Christophe Jamin, PhD · CHRU de Brest
-
Lenaig Le Clech, MD · CHRU Brest
-
Brigitte Pan-Petesh, MD · CHRU Brest
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2015-01-31
- Primary Completion
- 2015-09-30
- Completion
- 2015-09-30
Countries
- France
Study Locations
More Related Trials
-
Evaluation of Efficacy and Safety of Rituximab With Mycophenolate Mofetil in Patients With Interstitial Lung Diseases
NCT02990286 ·Status: COMPLETED ·Phase: PHASE3
-
Supporting Weak Immune System During Autoimmune Therapy: Testing Panzyga to Prevent Infections
NCT07220915 ·Status: NOT_YET_RECRUITING ·Phase: PHASE3
-
Patients Treated for Chronic Granulomatous Disease (CGD) Since 1995
NCT02082353 ·Status: UNKNOWN
-
Rituximab in the Treatment of Patients With Bullous Pemphigoid
NCT00286325 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Interest of Dosage of Anti-PB230, Anti-PB180 and Cytokines for Monitoring of Patients Suffering From Bullous Pemphigoid
NCT02883894 ·Status: COMPLETED
-
Analysis of Patients Treated for Chronic Granulomatous Disease Since January 1, 1995
NCT02116764 ·Status: COMPLETED
-
Pilot Study of Rituximab for Membranoproliferative Glomerulonephritis
NCT00275613 ·Status: COMPLETED ·Phase: PHASE1
-
Mutation of the BTK Gene and Genotype-phenotype Correlation of Chinese Patients With X-Linked Agammaglobulinemia
NCT02234791 ·Status: UNKNOWN
-
An In-vitro Standardization of B Cell Elispot Assays
NCT01334281 ·Status: TERMINATED
-
Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases
NCT01988506 ·Status: COMPLETED ·Phase: PHASE2
-
A Pilot Study of XOMA 052 in Familial Cold Autoinflammatory Syndrome / Muckle-Wells Syndrome and Behcet's Disease
NCT01211977 ·Status: WITHDRAWN ·Phase: PHASE1/PHASE2
-
A Long-term Safety Study of Infliximab (Remicade)
NCT00261976 ·Status: COMPLETED
-
A Study of the Safety and Effectiveness of Infliximab (Remicade) in Patients With Giant Cell Arteritis
NCT00076726 ·Status: TERMINATED ·Phase: PHASE2
-
Sirolimus for Autoimmune Disease of Blood Cells
NCT00392951 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Study to Investigate Efficacy, Safety and Pharmacokinetics of BT595 in Subjects With PID
NCT02810444 ·Status: COMPLETED ·Phase: PHASE3
-
Study of Gene Therapy Using a Lentiviral Vector to Treat X-linked Chronic Granulomatous Disease
NCT02234934 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
An Open Label Pilot Study Examining the Use of Rituximab in Patients With Wegener's Granulomatosis Who Have Experienced Disease Relapse on Standard Therapies
NCT00072592 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase IIa Study of Intravenous Rituximab in Pediatric Participants With Severe Granulomatosis With Polyangiitis (Wegener's) or Microscopic Polyangiitis
NCT01750697 ·Status: COMPLETED ·Phase: PHASE2
-
Abatacept to Treat Steroid Refractory Chronic Graft Versus Host Disease (cGVHD)
NCT01954979 ·Status: COMPLETED ·Phase: PHASE1
-
Infliximab Efficacy in Relation to Therapeutic Drug Monitoring and Serum TNFα Levels in Pediatric HSCT
NCT05825833 ·Status: COMPLETED
-
Study of Pregnyl as Adjunct Therapy for High-Risk or Refractory Acute GVHD
NCT02525029 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Ibrutinib in Combination With Corticosteroids vs Placebo in Combination With Corticosteroids in Participants With New Onset Chronic Graft Versus Host Disease (cGVHD)
NCT02959944 ·Status: COMPLETED ·Phase: PHASE3
-
COVID-19 Vaccine Responses in PIDD Subjects
NCT05321407 ·Status: ACTIVE_NOT_RECRUITING
-
A Study of Belimumab in the Prevention of Kidney Transplant Rejection
NCT01536379 ·Status: COMPLETED ·Phase: PHASE2
-
Study of the Frequency and of the Regulatory Function of Positive T Lymphocytes Dual CD4CD8aa (DP8a) Specific to a Bacteria of the Intestinal Microbiota (Faecalibacterium Prausnitzii) in Atopic Dermatitis, Asthma and Allergic Rhinitis
NCT02908360 ·Status: COMPLETED