Lymphocyte and Cytokine Disturbances in Polymyalgia Rheumatica
NCT02888496 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 40
Last updated 2016-09-05
Summary
Pathophysiology of polymyalgia rheumatica (PMR) is ill defined. This study aims at characterizing immunological abnormalities in PMR patients, and to assess the effects of tocilizumab therapy on this abnormalities.
Conditions
- Polymyalgia Rheumatica
Interventions
- DRUG
-
3 monthly IV infusions in PMR patients
Sponsors & Collaborators
-
University Hospital, Brest
lead OTHER
Principal Investigators
-
Divi Cornec · CHRU de Brest
Eligibility
- Min Age
- 18 Years
- Max Age
- 85 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2015-01-31
- Primary Completion
- 2015-06-30
- Completion
- 2015-06-30
Countries
- France
Study Locations
More Related Trials
-
Efficacy and Safety of Tocilizumab in Combination With DMARDs in Patients With Moderate to Severe Rheumatoid Arthritis
NCT01211834 ·Status: COMPLETED ·Phase: PHASE3
-
Rituximab Effect on Decreasing glUcoCorticoid Exposition in PolyMyalgia Rheumatica Patients Recently Diagnosed
NCT05533125 ·Status: COMPLETED ·Phase: PHASE3
-
Does Abatacept Induce Regulatory B Cells in Patients With Rheumatoid Arthritis
NCT02885818 ·Status: COMPLETED
-
Evaluation of the Condition of Rheumatoid Arthritis After Treatment
NCT02157012 ·Status: UNKNOWN ·Phase: PHASE4
-
A Rheumatoid Arthritis Study in Participants
NCT01202760 ·Status: COMPLETED ·Phase: PHASE3
-
Pharmaco Kinetic Variability of Infliximab in Rheumatoid Arthritis
NCT00840957 ·Status: COMPLETED
-
Gene Expression Profiling in PBMCs as a Tool for Prediction of Infliximab Responsiveness in Rheumatoid Arthritis
NCT00213564 ·Status: COMPLETED
-
Study on the Safety of Abatacept in Relapsing Polychondritis
NCT01272856 ·Status: COMPLETED ·Phase: PHASE1
-
Interest of Continuous Non-Steroidal Anti-Inflammatory Drug Treatment in Ankylosing Spondylitis Patients Treated by Anti-TNF Therapy in the Prevention of Radiographic Outcomes
NCT02469753 ·Status: COMPLETED ·Phase: PHASE3
-
Study of an Anti-TLR4 mAb in Rheumatoid Arthritis
NCT03241108 ·Status: COMPLETED ·Phase: PHASE2
-
Prospective Validation of a Pharmacological Biomarker for Low-Dose Rituximab in Rheumatoid Arthritis
NCT06933134 ·Status: RECRUITING
-
Identification of Factors Associated With the Occurrence of Severe Forms of COVID-19 Infection in Patients With Inflammatory Rheumatism or Autoimmune Diseases
NCT05026892 ·Status: UNKNOWN
-
Study of Abatacept Versus Placebo to Assess the Prevention of Rheumatoid Arthritis (RA) in Adult Patients
NCT00124449 ·Status: COMPLETED ·Phase: PHASE2
-
Relationship Between T LYmphocytes Depletion and Clinical Response to RITUXimab in Rheumatoid Arthritis (LYRITUX)
NCT02304354 ·Status: COMPLETED ·Phase: PHASE3
-
An Observational Study of Infliximab Injection in Ankylosing Spondylitis, Rheumatoid Arthritis, Psoriatic Arthritis and Psoriasis Participants
NCT00760669 ·Status: COMPLETED
-
Vaccination Against SARS-Cov2 (COVID-19) in Chronic Inflammatory Rheumatism and Factors Determining Its Decision.
NCT04970550 ·Status: COMPLETED
-
Infliximab Therapy in Patients With Refractory Polymyalgia Rheumatica
NCT01423591 ·Status: UNKNOWN ·Phase: PHASE3
-
A Study of Tocilizumab Plus Non-biological DMARD in Patients With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to Non-biological DMARDs
NCT01034397 ·Status: COMPLETED ·Phase: PHASE4
-
JAK-i on RA B-lymphocytes Tolerance and Disease Resolution Through JAK Signaling In Rheumatoid Arthritis
NCT05754112 ·Status: UNKNOWN
-
Abatacept vs Tocilizumab for the Treatment of RA in TNF Alpha Inhibitor Inadequate Responders
NCT03227419 ·Status: UNKNOWN ·Phase: PHASE4
-
Regulation of the Immune System in Response to the Treatment With Tocilizumab in Rheumatoid Arthritis Patients
NCT01633346 ·Status: COMPLETED
-
Vaccination Against Pneumococcal in Naïve Abatacept Rheumatoid Arthritis Patients
NCT02547493 ·Status: COMPLETED ·Phase: NA
-
A Safety and Pharmacokinetics Study in Participants With Rheumatoid Arthritis
NCT00380744 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Rheumatologic Adverse Events and Cancer Immunotherapy
NCT04791150 ·Status: UNKNOWN ·Phase: NA
-
Immunoregulatory Mechanisms of Treg Cells Induced by Tocilizumab
NCT02963402 ·Status: COMPLETED