Pilot Study of Cabozantinib for Recurrent or Progressive Central Nervous System Tumors in Children
NCT02885324 · Status: TERMINATED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 4
Last updated 2022-10-06
Summary
This pilot will study the feasibility and exploratory efficacy of using Cabozantinib for recurrent or refractory central nervous system tumors for which there are no curative options. Patients will also be followed for safety, time to progression, event free survival and overall survival
Conditions
- Glioblastoma Multiforme
- Anaplastic Astrocytoma
- Malignant Brain Tumor
- High Grade Glioma
Interventions
- DRUG
-
Subjects will receive Cabozantinib
Sponsors & Collaborators
-
Indiana University
lead OTHER
Principal Investigators
-
Scott Coven, DO · Indiana University School of Medicine
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 2 Years
- Max Age
- 21 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2017-05-18
- Primary Completion
- 2020-08-25
- Completion
- 2020-08-25
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Neoepitope-based Personalized Vaccine Approach in Pediatric Patients With Recurrent Brain Tumors
NCT03068832 ·Status: WITHDRAWN ·Phase: PHASE1
-
Vinblastine and Carboplatin in Treating Young Patients With Newly Diagnosed or Recurrent Low-Grade Glioma
NCT00352495 ·Status: COMPLETED ·Phase: PHASE1
-
Enzastaurin in Treating Young Patients With Refractory Primary CNS Tumors
NCT00503724 ·Status: COMPLETED ·Phase: PHASE1
-
Combination Chemotherapy in Treating Children With Progressive Brain Tumors
NCT00002944 ·Status: COMPLETED ·Phase: PHASE3
-
AZD2171 in Treating Young Patients With Recurrent, Progressive, or Refractory Primary CNS Tumors
NCT00326664 ·Status: COMPLETED ·Phase: PHASE1
-
PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors
NCT01158300 ·Status: COMPLETED ·Phase: PHASE1
-
Safety and Efficacy Study of TPI-287 in Neuroblastoma and Medulloblastoma
NCT01483820 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Prexasertib in Treating Pediatric Patients With Recurrent or Refractory Solid Tumors
NCT02808650 ·Status: COMPLETED ·Phase: PHASE1
-
Response and Biology-Based Risk Factor-Guided Therapy in Treating Younger Patients With Non-high Risk Neuroblastoma
NCT02176967 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT-Driven Medulloblastoma
NCT02724579 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Pazopanib Hydrochloride in Treating Young Patients With Solid Tumors That Have Relapsed or Not Responded to Treatment
NCT00929903 ·Status: COMPLETED ·Phase: PHASE1
-
Biological Therapy in Treating Children With Refractory or Recurrent Neuroblastoma or Other Tumors
NCT00003750 ·Status: COMPLETED ·Phase: PHASE1
-
Carboplatin and Irinotecan in Treating Children With Refractory Solid Tumors
NCT00024284 ·Status: COMPLETED ·Phase: PHASE1
-
Carboplatin and Vincristine Plus Radiation Therapy Followed By Adjuvant Chemotherapy in Treating Young Patients With Newly Diagnosed CNS Embryonal Tumors
NCT00003203 ·Status: COMPLETED ·Phase: PHASE2
-
HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors
NCT02875314 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE4
-
Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation
NCT06942039 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Trebananib in Treating Younger Patients With Relapsed or Refractory Solid Tumors, Including Central Nervous System Tumors
NCT01538095 ·Status: COMPLETED ·Phase: PHASE1
-
Intra-arterial Chemotherapy for Advanced Intraocular Retinoblastoma
NCT01151748 ·Status: WITHDRAWN ·Phase: PHASE2
-
Combination Chemotherapy Followed By Peripheral Stem Cell Transplant in Treating Young Patients With Newly Diagnosed Supratentorial Primitive Neuroectodermal Tumors or High-Risk Medulloblastoma
NCT00336024 ·Status: COMPLETED ·Phase: PHASE3
-
Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery
NCT03904862 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Brain Tumor
NCT00003273 ·Status: WITHDRAWN ·Phase: PHASE2
-
Selecting Patient-Specific Biologically Targeted Therapy for Pediatric Patients With Refractory Or Recurrent Brain Tumors
NCT02015728 ·Status: UNKNOWN ·Phase: NA
-
GVAX Plus Checkpoint Blockade in Neuroblastoma
NCT04239040 ·Status: TERMINATED ·Phase: PHASE1
-
Chimeric Natural Killer Receptor-Universal T Cells for Relapsed or Refractory Neuroblastoma
NCT06751134 ·Status: RECRUITING ·Phase: PHASE1
-
Gene Therapy in Treating Children With Refractory or Recurrent Neuroblastoma
NCT00002748 ·Status: COMPLETED ·Phase: PHASE1