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Apoptotic Signaling Pathways in Rats With Endometrial Hyperplasia

NCT02872818 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2016-08-23

No results posted yet for this study

Summary

The purpose of the study is to determine apoptotic signaling pathways such as Survivin, Bcl-2, Bax, c-Myc and caspase-9 expression levels in rats model with iatrogenic endometrial hyperplasia after metformin and medroxyprogesterone acetate administration.

Conditions

  • Apoptotic Signal Pathways in Endometrial Hyperplasia

Interventions

DRUG

17β estradiol hemihydrate

4mg/kg/day for 20 days

DRUG

Metformin

50 mg/kg/day last 10 days

DRUG

medroxyprogesterone acetate

1mg/kg/day last 10 days

Sponsors & Collaborators

  • Kayseri Education and Research Hospital

    lead OTHER_GOV

Principal Investigators

  • Erdem SAHİN · Kayseri Training and Research Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
8 Weeks
Max Age
10 Weeks
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-10-31
Primary Completion
2015-03-31
Completion
2015-03-31

Countries

  • Turkey (Türkiye)

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02872818 on ClinicalTrials.gov