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Unlock the Cell: Castleman's Disease Flow Cytometry Study

NCT02853968 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 130

Last updated 2020-03-26

No results posted yet for this study

Summary

Castleman disease, a rare lymphoproliferative disorder, is characterized by inflammatory cytokine production and multiple organ system dysfunction. In this study, we will investigate inflammatory markers, cells, and signaling pathways in prospectively collected blood samples and/or buccal swabs or saliva using biochemical and RT-PCR techniques, proteomics, genomics, immunohistochemistry, storage for future use, cell culture treated with external stimuli, flow cytometry, and other molecular tests

Conditions

  • Castleman Disease
  • Angiofollicular Lymphoid Hyperplasia
  • GLNH
  • Hyperplasia
  • Castleman's Disease
  • Angiofollicular Lymph Hyperplasia
  • Giant Lymph Node Hyperplasia

Interventions

PROCEDURE

Blood draw/buccal swab

The research project will need a blood sample of no more than 50mL per two month period. The research project may also request a buccal swab from patients if needed.

Sponsors & Collaborators

Principal Investigators

  • Vera Krymskaya, PhD, MBA · University of Pennsylvania

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-02-29
Primary Completion
2019-01-30
Completion
2019-03-30

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02853968 on ClinicalTrials.gov