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Changes in Resistome After Dental Extraction and Amoxicillin.

NCT02830347 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 16

Last updated 2017-10-27

No results posted yet for this study

Summary

The aim of this study is to evaluate the nature of the change in oral and gut bacterial resistance profiles after antibiotic therapy for a surgical procedure in two groups. The intervention group will receive a course of amoxicillin and analgesics after surgical extraction and have bacterial samples taken from saliva, tongue coatings and stool samples at four appointments over a period of six months. This will be compared to the control group which receive only analgesics after the surgical extraction.

An examination of the development and sustainability of antibiotic resistance in the oral and gut microbiome of healthy cohorts will be followed up for 6 months, after surgical extraction of impacted teeth.

Change in proportion of antibiotic resistant bacterial components will be studied using Metagenomic DNA sequencing and quantification of resistant genes .

Conditions

  • Impacted Third Molar Tooth

Interventions

DRUG

Amoxicillin

Extraction

PROCEDURE

Extraction

Extraction of third molars

Sponsors & Collaborators

  • The University of Hong Kong

    lead OTHER

Principal Investigators

  • Michael G Botelho, BDS MSc PhD · The University of Hong Kong

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-06-30
Primary Completion
2018-03-31
Completion
2018-03-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02830347 on ClinicalTrials.gov