MedTrace Logo

The Predictive Value of Amniotic Fluid pH and Electrolytes on Neonatal Respiratory Disorders

NCT02813954 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 184

Last updated 2022-08-18

No results posted yet for this study

Summary

Amniotic fluid (AF) is a complex structure with a changing content by gestational time. AF pH can be affected by both maternal and fetal conditions such as preterm ruptures of membranes, prematurity and fetal distress. While fetal urine is the major content of AF since 20th gestational week, fetal lung liquid (FLL) also acts as a minor content. Secretion of FLL depends on chloride transport and postnatal clearance of FLL is provided by active reabsorption of sodium (Na) ions. Down-regulation of epithelial Na channels (ENaCs) and an increase of pulmonary compliance accompany to pulmonary adaptation developing at the first hours of life. Lower genomic expression of Na channels in airways is shown to be associated to respiratory distress syndrome (RDS) in preterm. Although pH and electrolyte value of AF is thought to be relevant to fetal and maternal conditions such as gestational age, antenatal steroids and preterm birth, there is no study about this topic in the literature.

Conditions

  • Respiratory Distress Syndrome
  • Transient Tachypnea of Newborn

Interventions

DEVICE

Blood Gas Sampling

analyzing amniotic fluid by blood gas device

Sponsors & Collaborators

  • Kanuni Sultan Suleyman Training and Research Hospital

    lead OTHER

Principal Investigators

  • Seda Yilmaz Semerci · Postdoctoral Fellow of Neonatology

Eligibility

Max Age
25 Hours
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-08-31
Primary Completion
2016-04-30
Completion
2016-04-30

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02813954 on ClinicalTrials.gov