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Local IgE in Subjects With Allergic or Non-allergic Rhinitis

NCT02810535 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 150

Last updated 2017-11-30

No results posted yet for this study

Summary

The purpose of the study is to investigate the incidence of non-allergic rhinitis on a not selected group of young students (n=100-300). Students will be selected by public posting. In all students an allergy skin test will be performed. Then the local IgE of 24 subjects with non-allergic rhinitis will be compared to the local IgE of 24 subjects with allergic rhinitis and positive prick test to house dust mite. In addition 20 controlls will be investigated. Based on these investigations, the importance of local IgE and the IgE spectrum in conjunction with rhinitis should be further clarified.

Conditions

  • Perennial Rhinitis

Interventions

OTHER

Observation

Visit 1: * Physical examination (inspection of nasopharynx, auscultation of heart and lungs) * Completion of a Health Questionnaire * Lung function testing with spirometry * Skin prick test Visit 2: * Physical examination (inspection of nasopharynx, auscultation of heart and lungs) * Measurement of nitric oxide in expired air (FeNO) * Taking nasal secretion samples with a cotton carrier for 15 min * Nasal provocation test with dust mite * Blood sample collection to define blood count, IgE and specific IgE

Sponsors & Collaborators

  • Johann Wolfgang Goethe University Hospital

    lead OTHER

Principal Investigators

  • Stefan Zielen, Professor · Department for children and adolescents, division of allergy, pneumology, and cystic fibrosis

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-05-31
Primary Completion
2017-08-01
Completion
2017-09-19

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02810535 on ClinicalTrials.gov