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The Effects of ECT and/or iTBS on Olfaction and Cognition in Patients With Depression

NCT02804347 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2017-09-06

No results posted yet for this study

Summary

The sense of smell and cognition are known to be closely associated with mood and emotional processes. However, despite the clear links between olfaction and cognitive processes with emotional states, research into the role of olfaction, cognition, and mood disorders has so far yielded variable results. This study proposes to investigate the ability to detect and identify odours and assess cognition in a group of patients with unipolar and bipolar depression prior to and after receiving their scheduled electroconvulsive therapy (ECT) or intermittent theta burst stimulation (iTBS) treatments. Olfaction will be evaluated utilizing standard olfactory testing protocols using commercially available kits. Cognition will be evaluated utilizing standard cognitive test protocols in a functional magnetic resonance imaging protocol. The results will potentially shed light on the link between olfaction, cognition and mood disorders.

Conditions

Interventions

DEVICE

Cognitive Function Imaging and Battery

Individuals will be placed in the fMRI scanner and complete the NBACK Cognitive Task

DEVICE

Sniffin Sticks

Using Sniffin Sticks, olfactory functioning will be assessed using three tests: identification, discrimination, and threshold.

OTHER

Cognitive Batteries

Participants will conduct the following cognitive batteries: DSST, TMT A \& B, RAVLT

Sponsors & Collaborators

  • Providence Healthcare

    collaborator OTHER

  • Queen's University

    lead OTHER

Principal Investigators

  • Roumen V Milev, MD FRCPC · Queen's University Department of Psychiatry

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-03-31
Primary Completion
2017-07-31
Completion
2017-07-31

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02804347 on ClinicalTrials.gov