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Does Vitamin D Supplementation Enhance Resolution of Inflammation After Community-acquired Pneumonia?

NCT02802722 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 3

Last updated 2024-04-19

No results posted yet for this study

Summary

Previous research has shown that people who have been hospitalised for pneumonia are more likely to die of conditions such as heart attacks, stroke and cancer in the weeks to months after their illness. This risk is linked to raised levels of inflammation. Laboratory research shows that vitamin D can help to clear inflammation. Vitamin D deficiency is very common in the United Kingdom. The investigators are conducting this study to find out if taking vitamin D can hasten long-term recovery from pneumonia by reducing inflammation.

Conditions

Interventions

DIETARY_SUPPLEMENT

Vitamin D3 supplementation

Capsules to be dispensed using an electronic dispenser to allow real time logging of adherence.

BIOLOGICAL

Peripheral blood and induced sputum sampling

To attain samples for immunological testing

RADIATION

Chest computerised tomography (CT) scans

For volumetric quantification of lung abnormalities

OTHER

Symptom questionnaire

Symptom questionnaire for recent symptom history

OTHER

Placebo

To be dispensed using an electronic dispenser to allow real time logging of adherence.

Sponsors & Collaborators

  • Queen Mary University of London

    lead OTHER

Principal Investigators

  • Adrian Martineau, MBBS · Queen Mary University of London

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
SINGLE_GROUP

Eligibility

Min Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-02-24
Primary Completion
2018-12-31
Completion
2018-12-31

Countries

  • United Kingdom

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02802722 on ClinicalTrials.gov