Impact of Ban on Smoking in Pubs, Restaurants and Nightclubs on Endothelial Function in Workers

Summary

Endothelium is considered a real member, so it is contributing to determine the vascular homeostasis. The presence of endothelial dysfunction, evaluated in peripheral arteries by non-invasive study of the variation of gauge of the brachial artery as a result of post-ischemic hyperemia (FMD), is predictive of occurrence of major cardiovascular events. Several recent studies have shown that passive smoking is correlated with endothelial dysfunction and, therefore, non-smokers exposed subjects to passive smoking, have an increased risk of occurrence cardiovascular pathologies. From January 2008, a ministerial decree will ban smoking in bars, restaurants and nightclubs. The impact of exposure end to smoking in non-smoking subjects, as part of a prospective study and controlled, has never been evaluated.

Conditions

• Smoking

Interventions

OTHER

Medical interrogatory

Cardiovascular risk, medical history, known pathologies and actual treatments are evaluated

OTHER

Medical examination

Systolic blood pressure, diastolic blood pressure, cardiac frequency, pulse palpation, hearth and pulmonary auscultation

OTHER

Specific bioassay

Exhaled carbon monoxide measure and nicotine in the urine are evaluated

OTHER

Endothelial function evaluation

Endothelial function evaluation done by echotracking determining the basale flow mediated dilatation

OTHER

General bioassay

Fasting bioassay evaluating total cholesterol, low density lipoproteins, high density lipoproteins, triglycerides, creatine, transaminases, gamma glutamyl transferases, fibrinogen, reactive protein C, blood count and sedimentation rate.

Sponsors & Collaborators

• University Hospital, Toulouse

  lead OTHER

Principal Investigators

• Alessandra BURA-RIVIERE, MD · University Hospital, Toulouse

Study Design

Allocation

NON_RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2007-12-31

Primary Completion

2008-06-30

Completion

2008-06-30