Bypass Equipoise Sleeve Trial (BEST)

Summary

This is nationwide registry-based randomised clinical multicenter trial in which patients will be randomised to gastric bypass (RYGB) or sleeve gastrectomy (SG). The co-primary endpoint are weight control over 5 years and the amount of severe adverse events. Additionally the investigators have predefined a number of secondary endpoints, and the trial has a sufficient number of patients to allow comparisons across subgroups.

Conditions

• Severe Obesity

Interventions

OTHER

gastric bypass

Type of surgery: gastric bypass

OTHER

Sleeve gastrectomy

Typ of surgery: sleeve gastrectomy

Sponsors & Collaborators

• Ersta Hospital, Sweden

  collaborator OTHER

• Region Örebro County

  collaborator OTHER

• Kalmar County Hospital

  collaborator OTHER

• Lindesbergs Hospital

  collaborator UNKNOWN

• Danderyd Hospital

  collaborator OTHER

• Skaraborg Hospital

  collaborator OTHER_GOV

• Sodertalje Hospital

  collaborator OTHER

• Östra Hospital

  collaborator OTHER

• Mora Hospital

  collaborator UNKNOWN

• Torsby Hospital

  collaborator UNKNOWN

• Stockholm South General Hospital

  collaborator OTHER

• Gävle Hospital

  collaborator OTHER

• Uppsala University Hospital

  collaborator OTHER

• Lycksele Hospital

  collaborator UNKNOWN

• Falu Hospital

  collaborator OTHER

• Vrinnevi Hospital, Norrköping

  collaborator UNKNOWN

• Capio S:t Görans Hospital

  collaborator UNKNOWN

• Ljungby Hospital

  collaborator UNKNOWN

• Sykehuset i Vestfold HF

  collaborator OTHER

• Gjövik Hospital, Norway

  collaborator UNKNOWN

• GB Obesitas Skane

  collaborator OTHER

• Göteborg University

  lead OTHER

Principal Investigators

• Torsten Olbers, MD, PhD · Linköping University, Dept of BKV

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2015-09-30

Primary Completion

2026-12-31

Completion

2031-12-31

Countries

• Norway
• Sweden

Study Locations